What is Vitamin A Palmitate Used for?
Everyone has heard of vitamin A, but perhaps they have also heard of vitamin A palmitate, which is A derivative of vitamin A and a widely used raw material. Today, let's take a closer look at this vitamin A palmitate.
1. The vitamin A palmitate Brief introduction
Vitamin A palmitate also called Retinyl Palmitate, is a fat-soluble vitamin A derivative, with the chemical formula C36H60O2, pale yellow liquid, sensitive to air, heat, light and humidity, insoluble in water but soluble in ethanol, ether, chloroform, acetone and oils
Xi'an Season Biotech Vitamin A palmitate Specification.
|
Items |
Specifications |
Results |
|
Identification |
A.Transient blue color appears at once in presence of Antimony Trichloride TS |
Complies |
|
Absorbance Ratio |
The ration of corrected absorbance (A325) to the observed absorbance A325 is not less than 0.85 |
Complies |
|
Appearance |
Yellow or brown yellow oily liquid |
Complies |
|
Acidity |
≤1.0mgKOH/g |
0.40mgKOH/g |
|
Peroxide Value |
≤10meq/kg |
1.2meq/kg |
|
Heavy Metal |
≤10ppm |
Complies |
|
Lead |
≤2ppm |
<1ppm |
|
Arsenic |
≤1ppm |
<1ppm |
|
Vitamin A Palmitate Content |
≥1,700,000IU/g |
1,751,000IU/g |
|
The total content of the |
≤1.0% |
0.33% |
|
Total Plate Count |
≤1000cfu/g |
Complies |
|
Yeast & Mold |
≤100cfu/g |
Complies |
|
E. Coli |
Negative/10g |
Negative |
|
Salmonella |
Negative/25g |
Negative |
(We also supply the different specification Vitamin A palmitate powder, attached the 250CWS for reference,if you need other specification, pls kindly contact us)
|
Items |
Specification |
Results |
|
Appearance |
free-flowing powder |
free-flowing powder |
|
Colour |
Yellow |
Yellow |
|
Dispersibility |
CWS(Diffusion in cold water) |
CWS |
|
Fineness(US Standard Sieves) |
||
|
- through sieve No. 40 |
100 % smaller than 40 |
100 % |
|
- through sieve No. 60 |
min.90 % smaller than 60 |
94.2 % |
|
- through sieve No. 100 |
max.15 % smaller than 100 |
1.3 % |
|
Water content (%) |
≤8 |
4.4 |
|
heavy metals(以 Pb 计)% |
≤0.001 |
Conform |
|
(Arsenic)(以 As 计)% |
≤0.0001 |
Conform |
|
(Vitamin A Palmitate)(IU/g) |
250,000 |
251,000 |
|
Total bacterial count(cfu/g) |
≤5×103 |
Conform |
|
Coli form bacteria(MPN/100g) |
≤90 |
Conform |
|
Fungi and yeast(cfu/g) |
≤100 |
Conform |
|
Salmonella |
不得检出 Absence |
Conform |
|
Conclusion： The batch tested complies with USP,Ph.Eur.,DAB and BP monographs. |
||
2. What is vitamin A palmitate used for?
I. The Role in Dietary Supplements
Correct vitamin A deficiency
It can rapidly increase the serum retinol level for people with night blindness, dry eyes and low immunity.
Advantages: The esterification form has high stability, and the absorption rate (80-90%) after intestinal hydrolysis is significantly better than that of plant-based beta-carotene.
Prevent chronic diseases
Reduce the risk of certain cancers (such as lung cancer and stomach cancer) through antioxidant mechanisms and support the WHO's intensified program in deficient areas.
Ii. Applications in the Pharmaceutical Field
Treat diseases related to vitamin A deficiency
Prescription-level dose (up to 50,000 IU per day for adults) for:
Night blindness/Corneal dryness
Adjuvant treatment for children with measles (reducing mortality rate, recommended by WHO)
The blood drug concentration needs to be strictly monitored to avoid hepatotoxicity.
Special dosage form
Injection (for patients with severe absorption disorders)
Eye gel (for treating dry eye syndrome, such as retinol palmitate eye gel).
Note:
Medical-grade use requires a doctor's prescription. It is contraindicated for pregnant women (with teratogenic risk).
Iii. Functions in Cosmetics
Core anti-aging ingredients
Mechanism:
Promote the production of collagen and elastic fibers
Inhibit the degradation of collagen by matrix metalloproteinases (MMP)
Effect: Reduce wrinkles and improve skin roughness (clinically verified concentration: 0.1%-0.3%).
Acne treatment
Regulate keratinocyte differentiation and unblock clogged hair follicles (often combined with fruit acid and salicylic acid).
Light damage repair
Repair DNA damage caused by UV and reduce pigmentation (sunscreen is required).
Formula advantage
It is more stable and less irritating than free retinol, making it an entry-level product for sensitive skin.
Iv. Core Value of Food Fortifiers
Solve public health problems
Target audience:
Children in developing countries (Prevention of blindness/death caused by deficiency diseases)
Vegetarians (making up for insufficient intake of animal-derived VA)
Carrier selection:
Edible oils (lipid matrices such as palm oil and rapeseed oil)
Milk powder, grains, margarine
Technical advantage
Heat-resistant (stable below 180℃), suitable for frying food processing
Evenly dispersed in oils and fats, not prone to stratification (free retinol cannot achieve this)
Regulatory case
China: GB 14880 stipulates the addition amount of VA in vegetable oil (4-8 mg/kg)
The Philippines: The state has strengthened the edible oil program (reducing the deficiency rate among children by 40%).
3. Is vitamin A palmitate the same as retinol?
Differences in Chemical Nature and Structure
|
Character |
Vitamin A Palmitate |
Retinol |
|
Chemical type |
The retinol esterified form(retinol + palmitic acid) |
Free vitamin A (in alcohol form) |
|
molecular structure |
Larger, hydrophobic ester molecule (C36H60O2) |
Smaller polar molecules (C₂₀H₃₀O) |
|
solubility |
Fat-soluble (requires fat to assist in absorption) |
Liposoluble (but more prone to oxidation and inactivation |
|
Stability |
★★★★★ Ester bond protection, resistant to light heat/oxidation |
★★☆☆☆ Must be stored strictly away from light because It is extremely vulnerable to damage from light and oxygen |
Comparison of application scenarios
|
Character |
Vitamin A Palmitate |
Retinol |
|
Irritation |
Low (esterification buffer, suitable for sensitive skin) |
High (direct effect, prone to peeling/redness) |
|
Efficacy intensity |
Mild anti-aging (requires transformation, with gradual effects) |
Strong effect (directly activates the receptor, quickly reduces wrinkles. |
|
allowable conecntration |
0.3-1% (permitted by Chinese regulations) |
0.05-0.3% (EU limit: 0.05%) |
Comparison of using in food industry
|
Character |
Vitamin A Palmitate |
Retinol |
|
Applicability |
★★★★★ High-temperature resistant processing, can be added to edible oil/milk powder |
✘ Unstable and not suitable for food fortification |
|
Regulatory case |
Chinese GB 14880 allows fortified vegetable oils |
Prohibited for direct food addition |
|
allowable conecntration |
0.3-1% (permitted by Chinese regulations) |
0.05-0.3% (EU limit: 0.05%) |
Xi'an Season Biotechnology is specialized in R&D Production and sell the Natural plant extracts and health supplement cosmetic raw materials over 10years in China, with high quality, professional service and rich experience, can easily export to the world by air or sea.
If you're looking for the high quality Vitamin A Palmitate powder or Vitamin A Palmitate liquid, pls feel free to contact us!
Contact details:
Email: sales08@xaseason.com
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