What is Tauroursodeoxycholic acid Powder Used For?
TUDCA (tauroursodeoxycholic acid) is an artificially synthesized bile acid derivative, mainly used to improve liver function, promote bile excretion, and protect liver cells. It is widely applied in liver diseases, biliary tract diseases, and metabolic abnormalities. Today, let's take a deeper look at tauroursodeoxycholic acid through this article.
1.The brief introduction of TUDCA (tauroursodeoxycholic acid)
Taurodeoxycholic acid (TUDCA), chemically known as 3α, 7β -dihydroxycholanyl-n-taurine, is a conjugative bile acid formed by the shrinkage of the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine.
TUDCA was discovered in bear bile in 1902. It is the main bile acid in bear bile and has antispasmodic, anticonvulsant, anti-inflammatory and cholestolysis effects. tauroursodeoxycholic acid is an effective component of bear bile.
Xi'an Season Biotechnology TUDCA(tauroursodeoxycholic acid) specification data sheet
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ITEMS |
SPECIFIC |
RESULTS |
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Appearance |
White powder |
Confirmed |
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Rotation |
+58.0°- +61.0° |
+59.5° |
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Melting Point |
About 202℃ |
Confirmed |
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Tauroursodeoxycholic Acid |
Comparable IR absorption with the reference |
Confirmed |
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The spot is similar in position,color and size with the reference spot |
Confirmed |
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Blue-green precipitate occurs |
Confirmed |
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Related substances (TLC) |
Lithocholic Acid : n.m.t. 0.1% Chenodeoxycholic acid : n.m.t. 1.0% Cholic acid :n.m.t. 0.5% Any other single impurity:n.m.t. 0.25% |
Confirmed |
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Sulphated ash |
≤0.1% |
0.05% |
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Loss on drying |
≤1.0% |
0.12% |
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Heavy Metals(PPM) |
≤10.0PPM |
Confirmed |
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(TUDCA)Assay |
99%~101% |
99.72% |
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2.What is Tauroursodeoxycholic acid used for?
The mainly effects of Tauroursodeoxycholic acid:
(1)Liver cell protection
TUDCA can help repair damaged liver tissue by stabilizing liver cell membranes, reducing the accumulation of toxic bile acids, and inhibiting apoptosis (such as blocking apoptotic signals in the mitochondrial pathway). It is often used in clinical practice as an adjuvant treatment for liver diseases such as fatty liver, hepatitis and liver cirrhosis.
(2)Improving cholestasis
It can promote the secretion of bile acids, reduce the viscosity of bile, relieve symptoms such as skin itching and jaundice caused by biliary obstruction or bile excretion disorders, and has certain effects on diseases such as primary biliary cholangitis (PBC).
(3)Regulating cholesterol metabolism
TUDCA can inhibit the absorption of cholesterol in the intestines and promote the conversion of cholesterol into bile acids, thereby assisting in controlling hypercholesterolemia and reducing the risk of gallstones.
(4)Neuroprotective potential
Research shows that TUDCA may delay the progression of neurodegenerative diseases by reducing endoplasmic reticulum stress and inhibiting neuroinflammation. For instance, protective effects have been observed in animal models such as Alzheimer's disease and Parkinson's disease, but human evidence is still limited.
(5)Anti-inflammatory and Antioxidant
Alleviate tissue inflammatory responses by inhibiting the release of inflammatory factors such as NF-κB; At the same time, it enhances the activity of antioxidant enzymes and reduces the damage of free radicals to cells.
3.Is TUDCA the same as milk thistle?
It's different. Tauroursodeoxycholic Acid (TUDCA) and silymarin extract (whose core component is often silymarin) are two completely different substances, with significant differences in their sources, core mechanisms of action, and main application directions.
Although both are used to support liver health, they can be understood as having different "principles" and "areas of expertise" in protecting the liver.
The mainly difference of TUDCA & Milk Thistle Extract
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Tauroursodeoxycholic acid (TUDCA) |
Milk Thistle extract(silymarin) |
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Chemical nature and sources |
Bile acid derivatives of animal origin (extracted from bear bile/bovine bile or chemically synthesized). |
Flavonoid lignan complex from plant-based sources (milk thistle seeds). |
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Core mechanism of action |
"Chemical molecular chaperones" : Stabilize cell structure and resist apoptosis. |
"Antioxidants and Regeneration Promoters" : Powerful antioxidants, promoting liver cell regeneration. |
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Main application/research directions |
1. Treatment of liver and gallbladder diseases (cholestasis, litholysis). |
1. Chemical/toxic liver injury (alcohol, drugs, toxic mushrooms). |
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Source differences |
It is mainly of animal origin (the synthetic process also originated from this). |
Pure plant origin. |
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Research and regulatory status |
In some countries, it is a prescription drug, used in high doses for disease treatment, and research focuses on the deep mechanisms of cell protection. |
It is widely used as a dietary supplement/health product worldwide, with a long research history, and the evidence is mostly concentrated in the field of liver protection. |
4.What does TUDCA do to the brain?
Core mechanism of action: A "stabilizer" at the cellular level
TUDCA can cross the blood-brain barrier and enter the brain, directly acting on neurons and glial cells.
(1)Alleviating endoplasmic reticulum stress: This is the most renowned function of TUDCA. The neurons in the brain are highly active, and the endoplasmic reticulum, this "protein production and quality inspection workshop", is extremely prone to "going on strike" due to various pressures (such as the accumulation of misfolded proteins), leading to cell apoptosis. TUDCA can help stabilize the endoplasmic reticulum and maintain its normal function.
(2)Inhibiting mitochondrial pathway apoptosis: It can prevent mitochondria from releasing pro-apoptotic factors, blocking the cell's "suicide program" from the source.
(3)Anti-inflammatory and antioxidant: Alleviate chronic inflammatory responses and excessive activation of microglia in the brain, and help eliminate free radicals.
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