Palmitoyl Tetrapeptide-7(Pal GQPR)
When it comes to beauty peptides, everyone will think of copper peptides. Today, let's get to know another polypeptide ingredient widely used in cosmetics and skin care products: Pal GQPR/Palmitoyl Tetrapeptide-7/Matrixyl 3000 powder.
1.What is Palmitoyl Pal GQPR/Matrixyl 3000 powder/Tetrapeptide-7?
Palmitoyl tetrapeptide-7, also called Pal GQPR/Matrixyl 3000 powder, is a synthetic peptide composed of amino acids glutamine, glycine, arginine and proline. It is a skin repair ingredient renowned for its soothing ability, as it can interrupt the factors within the skin that cause signs of irritation (including exposure to UVB light) and loss of firmness signs. In this way, the skin can regain its firmness and undergo repair, thereby significantly reducing wrinkles.
In addition to the four amino acids, this peptide also contains the fatty acid palmitic acid to enhance stability and skin permeability.
Xi'an Season Biotechnology Pal GQPR specification data sheet:
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Items |
Specification |
Results |
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Appearance |
White or almost white powder |
Complies |
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Solubility |
Soluble in acetic acid, insoluble in water |
Complies |
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Water Content (Karl Fischer) |
≤8.0% |
3.4% |
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Peptide Purity (By HPLC) |
≥95.0% |
99.1% |
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Conclusion: the product conforms with enterprise standard and qualified |
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2.How does Pal GQPR/Matrixyl 3000 powder/Palmitoyl tetrapeptide-7 work?
The core mechanism of action of palmitoyl tetrapeptide-7 is cellular communication or signal transduction. It does not directly become a structural component of the skin (such as collagen), but acts as a "messenger" to convey specific "instructions" to skin cells (especially fibroblasts), regulating the physiological activities of the cells.
Its most significant and widely publicized function is anti-inflammation and delaying cellular aging. The specific pathways are as follows:
(1)Inhibit IL-6 inflammatory factor (core anti-inflammatory mechanism)
1)Background: When the skin is exposed to external stimuli such as ultraviolet (UV) rays, pollution, and stress, immune cells (such as macrophages) are activated and release a large amount of pro-inflammatory cytokines, among which interleukin-6 (IL-6) is a key factor.
2)Process: High levels of IL-6 can trigger a series of inflammatory responses, causing skin redness, swelling, tissue damage, and breaking down collagen and elastin, accelerating skin aging. This process is at the core of chronic inflammatory aging.
3)The function of palmitoyl tetrapeptide-7: Studies have shown that palmitoyl tetrapeptide-7 can effectively inhibit the excessive production of IL-6. It "soothes" the overactive immune response from the source by interfering with the synthesis or release signaling pathways of IL-6, thereby:
Reduce inflammation: Alleviate redness, swelling and sensitivity of the skin.
Reduce tissue damage: Protect the dermal matrix from inflammatory destruction.
3)Indirect protection of collagen: As inflammation is an important driving force for the breakdown of collagen, inhibiting inflammation is equivalent to providing a protective umbrella for collagen.
(2)Stimulate the synthesis of extracellular matrix
1)By creating a healthier and more "peaceful" cellular environment (reducing inflammation levels), fibroblasts can work more efficiently.
2)Although palmitoyl tetrapeptide-7 does not directly stimulate collagen production (which is the job of other peptides such as pentapeptide-3), it creates favorable conditions for the survival and stability of collagen through anti-inflammatory effects, indirectly helping to maintain the fullness and firmness of the dermis.
3.The main functions of Pal GQPR/Matrixyl 3000 powder/palmitoyl tetrapeptide-7 in skin care products
Based on the above mechanism, palmitoyl tetrapeptide-7 plays the following roles in skin care products:
(1)Powerful anti-inflammatory and soothing: Highly suitable for use in care formulas for sensitive skin, rosacea or damaged skin barriers. It can help relieve redness, burning and discomfort caused by external stimuli.
(2)Combating inflammatory aging: This is its most core value. Modern skin aging theory holds that chronic and low-grade inflammation is an important cause of aging. Palmitoyl tetrapeptide-7 directly targets this root cause and is thus hailed as a pioneering ingredient for "anti-inflammation and anti-aging". It helps to delay the formation of wrinkles, sagging and pigmentation caused by inflammation.
(3)Repair and maintenance: By protecting the existing collagen and elastin networks, it helps maintain the structural integrity of the dermis, making the skin look fuller and more elastic.
(4)Synergistic effect: It is rarely used alone and is usually compounded with other active ingredients to form a synergistic effect. For example:
1)When combined with palmitoyl tripeptide-1 or palmitoyl pentaptide-4: one is responsible for "anti-inflammatory protection", and the other for "stimulating new growth", jointly achieving a more comprehensive anti-aging effect.
2)When combined with antioxidants (such as vitamin C and E) : Antioxidants eliminate free radicals and reduce oxidative stress; Palmitoyl tetrapeptide-7 inhibits inflammatory responses, and the two work in synergy through different pathways to combat photoaging and environmental damage.
4.Pal GQPR/Matrixyl 3000 powder/Palmitoyl Tetrapeptide-7 Application and Usage
(1)Common product types: Due to its water-soluble properties, it is commonly found in products such as essence, lotion, face cream, eye cream and ampoules.
(2)Concentration: The addition concentration in skin care products is usually within the range of 1 to 10 ppm (parts per million). Although the concentration is extremely low, because it is an efficient signaling molecule, this concentration range has been proven sufficient to produce biological effects.
(3)Compatibility: It is stable in nature and can be well compatible with most other skin care ingredients, such as vitamins, other peptides, hyaluronic acid, niacinamide, etc.
(4)Usage suggestion: It can be used in the morning and evening. Daytime use can provide anti-inflammatory protection against environmental invasion. Using it at night is helpful for the skin's repair process. Because its functions are signal transmission and anti-inflammation rather than exfoliation, it is very suitable for all skin types, including sensitive skin.
Except for the Pal GQPR/Matrixyl 3000 powder/Palmitoyl Tetrapeptide-7, our hot sale cosmetic peptides products as following:
Acetyl Hexapeptide-8
AHK-CU
Biotin GHK
Acetyl Octapeptide-3
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-5
Acetyl Tripeptide-1
oligopeptide-1/2/6
Oligopeptide-68
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